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CA 15-3 (Breast Cancer)

CA 15-3, Cancer antigen 15-3 is a glycoprotein that has been found in benign malignant disease of the breast, as well as breast carcinoma that has metastasized to the liver or bone. It is highest CA-15-3 values are found in metastatic breast disease Testing for CA 15-3 is useful in the diagnosis of metastatic breast cancer and for the monitoring of patient response to breast cancer treatment- CA 15-3 value not increase may in early malignancy of the breast, it is not useful as a Screening test. Elevated CA 15-3 levels have also been found in patients without cancer and patients. with other cancer. such as liver, lung, and ovarian Cancer of the level of CA15-3 is higher the more advanced the breast cancer and the greater likelihood of metastasis.

Function OF CA 15-3:

CA 15-3 is a substance that stimulates your body’s defense system. Some kinds of cancer cells release the CA 15-3 antigen into the blood. The test is used for certain types of cancer. Breast cancer is cancer most likely to release CA 15-3, especially in breast cancer that comes back after treatment.

Risk Factors of Breast Cancer:

  • Getting older
  • Genetic mutations
  • Reproductive History
  • Having dense breasts
  • Family history of breast or ovarian cancer
  • Previous treatment using radiation therapy

Symptoms OF CA 15-3 (Breast cancer):

  • New lump in the breast or underarm (armpit)
  • Thickening or swelling of part of the breast
  • Irritation or dimpling of breast skin
  • Redness or flashy skin in the nipple area or the breast
  • Pain in the nipple area pulling in the ripple
  • Nipple discharge other than breast milk, including blood
  • Change the size and shape of the breast
  • Pain in any area of the breast

Normal Range Of CA 15-3:

CA 15-3 Less Than 30 U/ml

Causes Of High CA 15-3 Level:

  • Cirrhosis
  • Colon rectal Cancer (known as bowel, colon, or rectum cancer)
  • Fibrocystic breast disease
  • Liver Cancer
  • Lung Cancer
  • Metastatic Cancer
  • Sarcoidosis
  • Systemic Lupus Erythematosus
CA 15-3

How to perform the Test?

A blood sample was needed.


Take 3 to 5 ml of blood sample in a red top tube or gel tube. Centrifuge the blood sample and separate the serum. Take serum and run on Elisa or other special chemistry analyses like Architech.

By Mehfooz Ali

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7 thoughts on “CA 15-3”
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